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Point of Care Evaluation of Fibrinolysis in Sepsis

Point of Care Evaluation of Fibrinolysis in Sepsis

Recruiting
18 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Impaired fibrinolysis in septic patients is associated with worse outcome. The present study investigates fibrinolysis shutdown in septic patients, defined as prolonged ClotPro® TPA lysis time at 30 minutes. The TPA lysis time reference range is established in a cohort of healthy volunteers.

Eligibility

Inclusion Criteria:

  • age > 18 years
  • sepsis or septic shock
  • vasopressors required to maintain a MAP ≥ 65 mmHg despite adequate fluid resuscitation

Exclusion Criteria:

  • coagulation disorders
  • ECMO therapy
  • use of oral anticoagulant drugs

Study details
    Fibrinolytic Defect
    Sepsis
    Critical Illness

NCT06312488

Policlinico Hospital

22 March 2024

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