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Value of Heart Rate Lowering Therapy in Acute Myocarditis

Value of Heart Rate Lowering Therapy in Acute Myocarditis

Recruiting
18-90 years
All
Phase N/A
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Overview

To study the value of heart rate lowering therapy "pharmacological rest" on the short term in cases of myocarditis without LV dysfunction.

Eligibility

Inclusion Criteria:

  • Adults: ≥18 years of age.
  • Presentation: at least one of the following:
    • Myopericarditis/ACS-like
    • MINOCA
    • Arrhythmias: brady or tachyarrhythmias.
    • Unexplained compensated acute cardiomyopathy (excluded ischemic, valvular, hypertensive, metabolic, and toxic causes of cardiomyopathy as indicated clinically).
  • TTE: LVEF>40%
  • CMR-confirmed myo(peri)carditis (Lake Louise criteria)

Exclusion Criteria:

  • • Rheumatic carditis.
    • Connective tissue diseases (-ve ANA).
    • Cancer chemotherapy.
    • Toxicity from immunotherapy.
    • Vaccine-related myocarditis.
    • Presence of coronary artery disease.
    • Peripartum (occurring during the last month of pregnancy or within 5 months after delivery)
    • ECG: atrial fibrillation/flutter.
    • Resuscitated sudden death.
    • Early/initial phase of decompensated heart failure.
    • Tamponade complicating pericarditis unless successfully managed.

Study details
    Myocarditis

NCT06312891

Assiut University

20 March 2024

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