Overview
The purpose of this study is to investigate the one-year trajectory of changes in depression status in elderly patients with mild cognitive impairment and subthreshold depression, and to explore relevant risk factors for predicting changes in depression status. This one-year prospective longitudinal follow-up study involved 400 (expected) subjects who met the diagnostic criteria for mild cognitive impairment combined with subthreshold depression in the elderly, and their depressive status was assessed using the Geriatric Depression Scale (GDS). Follow up monitoring of depression status at 6 and 12 months. Obtain factors related to changes in depressive status (such as age, gender, education level, cognitive function, anxiety level, sleep status, social support, psychological resilience, social network, etc.). By studying the longitudinal trajectory of depression status in elderly patients with mild cognitive impairment and subthreshold depression, a multi state Markov model with time and state discreteness is constructed, namely: State 1 (normal); State 2 (subliminal depression); State 3 (mild depression); State 4 (moderate depression); State 5 (severe depression). Deeply explore and analyze the impact of certain factors and indicators on the transition between states, and estimate the probability of transition between states.
Eligibility
Inclusion Criteria:
- Age: ≥ 60 years old
- Meets the diagnostic criteria for mild cognitive impairment and subthreshold depression
- Having basic comprehension and verbal expression skills
- Voluntarily participate in this study and sign an informed consent form.
Exclusion Criteria:
- Diagnosed as depression patients, including patients with organic mental disorders and patients with a history of depression related mental disorders
- Cognitive impairment caused by other diseases (such as neurological and psychiatric disorders, metabolic disorders, poisoning, infections, etc.)
- Severe heart, liver, and kidney diseases
- Serious chronic diseases and complications, such as congestive heart failure, hypertension, diabetes and other diseases with serious complications