Overview

The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa. The main questions the study aims to answer are:

• What is the best tolerated dose and are there any side effects, in particular any inflammatory reactions post drug administration?
• Are there any early signs of efficacy on visual function?

Participants will be administered a single intravitreal dose of VG901 into the most affected eye through a syringe and followed up for a year to monitor safety and efficacy. There will be two cohorts of participants in this study. Study Cohort 1 will receive the low dose and Study Cohort 2 will receive the high dose as specified in the Protocol.

Eligibility

Inclusion Criteria:

To be eligible for study entry, subjects must satisfy all the following criteria:

1. Able to understand and willing to consent to study participation by a written informed consent
2. Male or female ≥ 18 years of age
3. Clinical diagnosis of RP
4. Confirmed pathogenic, biallelic variants in the CNGA1 gene
5. Ellipsoid zone (EZ) length of the fovea of ≥ 3000 μm in the study eye

Exclusion Criteria:

        Subjects will be excluded from the study if one or more of the following statements are
        applicable to either eye:
          1. Additional interfering ocular conditions which would impact study results (e.g.,
             ocular opacity and advanced cataract, uveitis, amblyopia)
          2. History or presence of glaucoma
          3. Ocular surgery, intravitreal or subretinal implantation of a medical device (within 6
             months of screening)
          4. Mutations known to cause inherited retinal disease other than biallelic variants in
             the CNGA1 gene
          5. History of ocular infection with herpes simplex virus
          6. History of ocular malignancies
          7. History of disorders of the internal retina (e.g., retinal detachment)
          8. Patients with uncontrolled diabetes (HbA1c > 7%)
          9. Any other retinopathy due to other diseases - including, but not limited to arterial
             hypertension, previous vascular retinal occlusion, trauma or acquired inflammatory
             diseases, contraindication to pharmacological mydriasis (e.g., history of angle block
             glaucoma), diabetes (diabetic retinopathy including macular oedema)
         10. Absence of visual function on the contralateral eye
         11. Any damage to the optic nerve
         12. Individuals performing any other therapy for RP within 3 months before the study, such
             as - but not limited to - transcorneal electrostimulation
         13. Systemic conditions (e.g., autoimmune disorders) which may affect study participation
             or outcome measures
         14. History of immunodeficiency or other medical conditions which may increase the risk of
             VG901 administration
         15. Systemic illness (e.g., hepatitis or human immunodeficiency virus [HIV] infection) or
             medically relevant abnormal laboratory values (3 x upper limit of normal [ULN]) in
             blood analysis including renal and hepatic function
         16. Current, or recent, participation in other study/ or administration of investigational
             biologic agent within 3 months of Screening; Use of any investigational agent, or
             systemic corticosteroids, or other immunosuppressive drug(s) within 3 months before
             Screening
         17. History of allergy or sensitivity to any compound used in the study
         18. Contraindications to systemic immunosuppression
         19. Subjects with increased risk of bleeding (i.e., use of anticoagulants or anti-platelet
             agents within 7 days before VG901 administration and subjects with international
             normalized ratio > 2 or Quick < 50% or partial thromboplastin time > 50 seconds,
             thrombocytopenia, as well as any other known coagulopathy)
         20. Subject/partner of childbearing potential unwilling to use adequate contraception for
             the period between Screening and 30 days after treatment, defined as the period from
             Screening until 30 days after treatment (defined as administration of therapeutic to
             the eye)
         21. For females of childbearing potential, a positive pregnancy test at Screening or
             Baseline
         22. Females who are breastfeeding
         23. Previous receipt of any AAV gene therapy product
         24. Any condition which leads the investigator to believe that subject cannot comply with
             the protocol requirements or that may place the subject at an unacceptable risk from
             participating