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Cognitive-behavioral Therapy vs. Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder

Cognitive-behavioral Therapy vs. Nutrition Counseling for Avoidant/Restrictive Food Intake Disorder

Recruiting
10-18 years
All
Phase N/A

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Overview

This study is a randomized controlledlinical trial, assessing the efficacy of cognitivebehavioral therapy (CBT-AR) and nutrition counseling for avoidant/restrictive food intake disorder (ARFID) for children and adolescents (ages 10-18 years).

Eligibility

Inclusion Criteria:

  • Males and Females ages 10-18 years old
  • Current ARFID
  • Normal TSH or free T4 levels to rule out thyroid disease as cause of symptoms
  • Negative celiac screening panel indicating no active celiac disease as cause of symptoms
  • Fluency and literacy in English

Exclusion Criteria:

  • BMI < 5th percentile for sex and age
  • Pregnancy, breastfeeding, or recent initiation/cessation of oral contraceptive pills within 8 weeks of the pre-treatment study visit
  • Current/history of psychosis
  • Substance/alcohol use disorder (active within the past month)
  • Medical instability requiring inpatient care according to the American Psychiatric Association 2023 treatment guidelines for eating disorders
  • Laboratory abnormalities indicating a need for higher level of care
  • Complete lack of oral intake (suggesting a need for inpatient care)
  • Tube feeding (suggesting a need for tube weaning)
  • Active suicidal/homicidal ideation with intent or plan
  • Contraindications to MRI
  • History of major gastrointestinal tract surgery or serious medical condition (e.g., cancer)
  • Medical history of intellectual disability
  • Illiteracy

Study details
    Avoidant/Restrictive Food Intake Disorder (ARFID)

NCT05954728

Massachusetts General Hospital

14 July 2025

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