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Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Using Tissue-based Spatial Data to Understand How Obesity-related Tumor Metabolites Fuel Prostate Cancer Progression

Recruiting
18 years and older
Male
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI > 27.5) and non-severely overweight/normoweight (BMI < 27.5) patients affected by prostate carcinoma.

ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.

iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.

Eligibility

Inclusion Criteria:

  • affected by prostate cancer

Exclusion Criteria:

-

Study details
    Prostate Cancer
    Prostate Adenocarcinoma
    Prostate Neoplasm
    Prostatic Neoplasm
    Obesity

NCT06292897

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

7 March 2024

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