Description

Transient ischemic attack (TIA) and acute minor ischemic stroke, are common and may leave impermanent or mild neurological deficit, they are termed as non-disabling ischemic cerebrovascular disease (NICE). TIA and minor stroke exhibit the common substantial risk factors for early stroke recurrence and epidemiological characteristic, with approximately 10 to 20% of patients having a stroke within 3 months after the index event.

Previous studies has shown that post-stroke apathy (PSA) affects one in three stroke patients, which is consistently associated with a worse level of functional recovery, poorer overall health and poorer quality of life. However, still little is known about the development of TIA and minor stroke patients with apathy. Thus, it is imperative to find the relationships between baseline PSA and probable incident stroke in these patients.

NICE is an attractive researching area globally. According to the large quantities of NICE patients in China and the low standardized therapeutic rate, the awareness of TIA and minor stroke is largely insufficient. The purpose of the present NICE-A study is to establish the prevalence, predictors and evolution of symptoms of PSA in TIA and minor stroke patients during the first post-stroke year.

        ≥18 years old Onset of a minor stroke (National Institute of Health stroke scale, NIHSS≤3)
        and TIA elapsed time from last episode to registry <1 month
        Exclusion Criteria:
        patients who refused to participate in the research, and patients who failed to complete
        the follow-up protocol.
        patients with malignant tumors, or patients with severe liver or kidney disease, whose life
        expectancy is less than 1 year.
        patients who received endovascular or thrombolytic therapy.