Overview
The incident of epilepsy still very high in Indonesia, thus many patients become drug resistant epilepsy. As vitamin D has some anticonvulsant effect, the investigators want to study if an additional dose of vitamin D can help with the therapy responses.
Description
Specifically the investigators want to study about :
- Correlation between serum vitamin D levels and seizure frequency change after vitamin D treatment
- Correlation between serum GDNF levels and seizure frequency change after vitamin D treatment
- Correlation between serum Interleukin-1ß levels and seizure frequency change after vitamin D treatment
- Responder rate. Percentage of patients change of at least 50% of the seizure frequency
- Remission rate after vitamin D treatment. Percentage of patients without any seizure (seizure freedom)
- Effect of vitamin D according to epilepsy type. Responder rate in focal and generalized epilepsy.
- Effect on Global Assesment of the Severity of Epilepsy (GASE)
- Effect on Hague Seizure Severity scale (HASS)
- Effect on Quality of Life in Epilepsy in Children: (QOLCE 55)
Eligibility
Inclusion Criteria:
- Age 1 - 18 years
- Drug-resistant epilepsy
- Having at least 6 unprovoked seizures in the previous 3 months
- No vitamin D treatment in the previous 6 months
- Medication compliance
- Agreeing to participate in the study
- Having a social insurance
- Parental agreement
Exclusion Criteria:
- Treatments influencing the metabolism of vitamin D other than anticoagulants (rifamycin, isoniazid, ketoconazole, 5-FU fluorouracil, leucovorin)
- Known hypersensitivity to vitamin D
- Lost to follow up