Overview
The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed tomography(CT)-derived fractional flow reserve(FFR), and (2) to demonstrate difference in clinical outcomes between the 2 groups.
Description
The CABG-COREA trial is designed as a randomized, controlled trial to recruit 96 patients who undergo coronary artery bypass grafting. Patients were randomized by use of a randomization table. Coronary arteries are revascularized based on conventional coronary angiography or cardiac computed tomography-derived fractional flow reserve according to the randomization result.
The primary end point is to evaluate early and 1-year postoperative graft patency. The secondary end points are overall survival, freedom from cardiac death and freedom from MACCE(major adverse cardiac or cerebrovascular events).
Eligibility
Inclusion Criteria:
- age equal or more than 40
- age equal or less than 80
- patients who undergo coronary artery bypass grafting due to multi-vessel coronary artery disease
- patients who agree to the enrollment
Exclusion Criteria:
- Patients with heart failure (left ventricular ejection fraction < 25%)
- patients who have intractable ventricular arrhythmia
- patients who has been treated for cancer
- patients who has infectious disease
- patients who are planned to undergo combined cardiac surgery
- patients who has medical co-morbidity with expected survival less than 1 year
- patients with a history of previous cardiac surgery
- Patients with chronic renal failure requiring dialysis
- patients who undergo emergency operation