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A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

Recruiting
18 years of age
Both
Phase 3
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Overview

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Eligibility

Inclusion Criteria:

  • B/S1 hypertension; SBP 120-139 average based on 3 office measurements.
  • COA Repair prior to age 10
  • No residual COA; Based on mean doppler COA gradient <20mmHg within past 12 months

Exclusion Criteria:

  • Currently on beta blocker (BB) therapy
  • Pregnancy/lactating
  • eGFR<30
  • Hyperkalemia (serum potassium >5.5mmol/L)
  • Severe Aortic or Mitral valve stenosis or regurgitation
  • Epicardial CAD diagnosis
  • Received antihypertensive medications within the past year

Study details

Coarctation of Aorta, High Blood Pressure

NCT06150560

Mayo Clinic

29 May 2024

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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