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Estrogen Receptors and HER2 Levels' Expression in Luminal Metastatic Breast Cancer

Estrogen Receptors and HER2 Levels' Expression in Luminal Metastatic Breast Cancer

Recruiting
18 years and older
All
Phase N/A
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Overview

CYCLHER is a retrospective observational multicentric italian study aimed to evaluate the correlation between hormone receptors (HR) and HER2 immunohistochemistry (IHC) levels and treatment'response in patients affected by advanced breast cancer treated with first line CDK4/6 inhibitor plus endocrine therapy.

Eligibility

Inclusion Criteria:

  • Age ≥ 18 yo
  • Histological diagnosis of HR+/HER2- advanced breast cancer
  • Immunohistochemical HER2 negative evaluation (0, 1+ or 2+ FISH-)
  • Immunohistochemical expression levels of estrogen and progesterone receptors
  • First line CDK4/6 inhibitor plus endocrine therapy stared up to 12/31/2020
  • Signing of informed consent approved by local Ethic Committee

Exclusion Criteria:

  • Absence of clinical and pathological data that would compromise the definition of the study endpoints
  • HER2 positive (ICH 2+ and FISH positive or HER2 3 +) or triple negative disease
  • Previous chemotherapy for treatment of metastatic disease

Study details
    Advanced Breast Carcinoma

NCT06243432

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

2 May 2024

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