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The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

Recruiting
18 years and older
All
Phase N/A
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Overview

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).

Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

Description

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).

Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

The aim of this study is to determine the survival, functional and quality of life outcomes of patients undergoing all salvage surgery for recurrent, residual and new primary head and neck SCC, and to establish the genetic architecture and clonal evolution H&N SCC after previous treatment for radiotherapy cancer.

Eligibility

Inclusion Criteria:

  1. Aged over 18
  2. Previous H&N SCC treated with radiotherapy with or without chemotherapy
  3. Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx
  4. Ability to give informed consent for biological sample collection (molecular analysis study only)

Exclusion Criteria:

  1. Nasopharyngeal and cutaneous SCC of the H&N
  2. Thyroid, salivary gland, and non-squamous cell H&N cancers
  3. Presence of distant metastasis (M1) or surgically inoperable T4b tumours

Study details
    Head and Neck Cancer

NCT05808920

Royal Marsden NHS Foundation Trust

17 May 2024

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