Overview

This study aim to evaluate whether a dose of 5 mg of lemborexant, as compared to a placebo, may improve daytime recovery sleep, without producing lingering sleepiness during wakefulness, using a 3-day simulated night shift protocol in the lab under constant monitoring.

Eligibility

Inclusion Criteria:

        Participants must fulfill all of the following inclusion criteria to be eligible for
        inclusion in this study:
          1. Men or women aged between 30 and 60 years, inclusive
          2. Be willing and able to give informed consent for study participation
          3. Participants must not have done shiftwork in the past year
          4. Normal vital signs values are: oral body temperature between 36.1 and 37.5 ºC (95 and
             99.5 °F), supine SBP between 90 and 140 mmHg inclusive; supine DBP between 55 and 90
             mmHg inclusive; heart rate between 50 and 100 bpm inclusive.
          5. Be willing to comply with all study requirements and procedures for the duration of
             the study, including refraining from consuming alcohol 48 hours prior to each
             experimental visit and grapefruit products (juice or fruit itself), Seville orange,
             lime, pomelo, carambola and pomegranate during all the duration of the study (from
             Visit 1 to Visit 4).
          6. Women who:
               -  Are postmenopausal, with amenorrhea for at least 1 year before the screening
                  visit, OR
               -  Are surgically sterile, OR
               -  If of childbearing potential agree to practice effective double barrier methods
                  of contraception, from the time of the signing of informed consent through the
                  last dose of study drug and for 30 days after dosing stops (1 ovulatory cycle),
                  or agree to completely abstain from intercourse.
             Men with women partners of childbearing potential are also expected to practice
             effective barrier methods of contraception from the time of signing informed consent
             through the last dose of study drug and for 30 days after dosing stops.
          7. Self-reported bedtime was between 9 pm and midnight on 4-7 nights per week.
        Exclusion Criteria:
        Participants must not meet any of the following exclusion criteria:
          1. Body mass index > 32 as calculated from the participant's height (m) and weight (kg);
             weight (kg)/square height (m²)
          2. Presence of a sleep disorder, such as a diagnosis of insomnia, narcolepsy, sleep
             paralysis, active somnambulism (history of childhood somnambulism is accepted),
             hypnagogic/ hypnopompic hallucinations, and REM behavior disorder, will be excluded
             based on the clinical interview. For sleep apnea syndrome, an apnea-hypopnea index >
             15 per hour of sleep on the first screening night will be used as an exclusion
             criterion. For periodic limb movement disorder, an index of periodic limb movements
             during sleep associated with an arousal > 15 per hour of sleep on the first screening
             night will be used as an exclusion criterion.
          3. History of epilepsy
          4. Any previous serious head injury or stroke
          5. Any evidence of psychiatric disorder (including Beck Depression Inventory [BDI] ≥ 20
             at screening, or a score of 3 on item related to suicidal ideas)
          6. Evidence of any clinically significant, or unstable, acute or chronically progressive
             medical or surgical disorder (including planned medical procedures that may impact
             sleep), or any condition that may interfere with the absorption, metabolism,
             distribution, or excretion of the study drug, or may affect the participant's safety
          7. Clinically significant and abnormal electrocardiogram (ECG; including QTc ≥ 450 ms for
             males, 460 ms for females) or a history of cardiovascular disease including poorly
             controlled hypertension, ischemic heart disease, arrhythmia, or severe heart failure
          8. Severe hepatic impairment
          9. Positive qualitative urine drug screen (opiates, cocaine, amphetamine, cannabinoids,
             barbiturates, phencyclidine, benzodiazepines, methadone, propoxyphene) and alcohol
             test (breathalyzer), at screening and before each experimental visit
         10. Current use of medications that are moderate or strong CYP3A4 inhibitors or inducers
             or CYP2B6 substrates (Appendix 1)
         11. Use of any substance with psychotropic effects or properties known to affect
             sleep/wake, including hypnotics, neuroleptics, opioid derivatives, antihistamines,
             stimulants, antidepressants, within one week or five half-lives (whichever is longer)
             prior to PSG screening
         12. Use of any over-the-counter sleep medications including tryptophan, valerian root
             (Valeriana officinalis), kava (Piper methysticum Forst), melatonin, St John's Wort
             (Hypericum perforatum), Alluna (herbal sleep supplement with valerian root), and hemp
             within one week or five half-lives (whichever is longer) prior to screening
         13. Consumption of xanthine-containing beverages (i.e., tea, coffee, or cola) of more than
             5 cups or glasses per day
         14. Participation in any other trial within 30 days before the screening visit
         15. Any travel across more than one time zone in the month prior to screening at any time
             during the study
         16. Other exclusion criteria based on adverse events (AE) or serious adverse events (SAE)
             reported in the Investigator Brochure
         17. Women who are pregnant, during the study or within one month after the study, or are
             breastfeeding
         18. Individuals may be excluded from participating in the study based on the clinician's
             judgement.
         19. Participants with lactose or galactose intolerance (galactosemia or glucose-galactose
             malabsorption)