Overview
This study will investigate the efficacy and safety of "deep" rTMS on neuropathic pain or fibromyalgia. It will be randomized and sham controlled and will last 3 months. Patients will be randomized to receive acctive rTMS or sham rTMS and will receive repeated rTMS sessions (5 daily sessions then one session per week then every 2 to 3 weeks for up to 10 weeks).
Description
This double blind sham controlled parallel group bicenter study will assess the efficacy and safety of repeated sessions of deep rTMS using H coil in patients with neuropathic pain or fibromyalgia. Primary outcome will be % of pain relief at week 13.
Eligibility
Inclusion Criteria:
- Chronic pain ≥ 6 months, at least 4/10 on a 0-10 NRS, present every day or nearly every day
- Neuropathic pain (confirmed with Douleur Neuropathique en 4 questions and international criteria from NeuPSIG) or fibromyalgia (revised ACR criteria)
- Stable concomitant medications for pain for at least one month
- Able to fill out questionnaires and understand and speak French
Exclusion Criteria:
- Contraindications to rTMS
- Prior treatment with rTMS
- Progressive severe condition (eg cancer)
- Psychosis
- Psychoactive drug abuse