Overview
This is a randomized, double-blind, placebo-controlled, cross-over trial investigating the effects of daily administration of citrus extract on sleep and mental wellbeing.
Description
Based on epidemiological data, a substantial number of people report to have sleeping problems. This is of major concern, as poor sleep quality has been associated with impaired mental and physical health. Several pre-clinical studies have shown promising results, but evidence from human studies is still limited. Therefore, the aim of the present study is to investigate the effect of a citrus extract on sleep and mental wellbeing in healthy subjects with (minor) sleep disturbance.
Eligibility
Inclusion Criteria:
- Healthy individuals with (minor) sleep disturbance
- Age 40-70 years
- BMI 18.5 - 30 kg/m2
- Willingness to give up being a blood donor from 4 weeks before the start of the study, during the study and for 4 weeks after completion of the study
Exclusion Criteria:
- Excessive caffeine use
- Major psychiatric/mental health disorders .
- Chronic sleep disorders
- Severe sleep disturbance for more than 1 year
- Other clear causes for poor sleep quality or mental wellbeing
- Use of medication or supplements that can affect outcomes
- Nonpharmacological treatment for sleep disorders
- Flight from a time-zone with >3 h difference ≤1 week before an intervention period
- Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study
- Use of pre-, pro- or synbiotics within 1 month prior to the start of the study
- Reported weight loss or weight gain of >3 kg in the month prior to pre-study screening
- Smoking
- Abuse of products
- Known allergy to citruses
- Known pregnancy or lactation