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Prediction, Prevention, Predisposition: Applications in Neurology and Endocrinology

Recruiting
18 - 80 years of age
Both
Phase N/A

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Overview

This project aims to introduce solutions for strengthening the management capabilities of two types of patients, in terms of care and prevention. Specifically, it is aimed at neurological patients with mild or minor neurocognitive decline (Mild Cognitive Impairment, MCI) and endocrinological patients diagnosed with obesity. The study want to enhance the predictive capacity of the care process management system through an Artificial Intelligence (AI) system. All patients diagnosed with MCI and obesity who, within 30 months, will be referred to the Neurology and Endocrinology clinics of the IRCCS Centro Neurolesi Bonino-Pulejo in Messina will be evaluated.

Study design

Patients will not be subjected to any procedure that goes beyond normal clinical practice; the clinical and neuropsychological variables that will be collected for the study are those that are commonly collected in normal clinical practice. All patients diagnosed with MCI and obesity who, within 30 months, will be referred to the Neurology and Endocrinology clinics of the IRCCS Centro Neurolesi Bonino-Pulejo in Messina will be evaluated.

All patients will undergo clinical, neuropsychological and psychological evaluation at the beginning (baseline T0), at the end (T1) and after ... months from the end of treatment (follow up T2).

Description

This project aims to introduce solutions for strengthening the management capabilities of two types of patients, in terms of care and prevention. Specifically, it is aimed at neurological patients with mild or minor neurocognitive decline (Mild Cognitive Impairment, MCI) and endocrinological patients diagnosed with obesity. The study want to enhance the predictive capacity of the care process management system through an Artificial Intelligence (AI) system. All patients diagnosed with MCI and obesity who, within 30 months, will be referred to the Neurology and Endocrinology clinics of the IRCCS Centro Neurolesi Bonino-Pulejo in Messina will be evaluated.

Study design

Patients will not be subjected to any procedure that goes beyond normal clinical practice; the clinical and neuropsychological variables that will be collected for the study are those that are commonly collected in normal clinical practice. All patients diagnosed with MCI and obesity who, within 30 months, will be referred to the Neurology and Endocrinology clinics of the IRCCS Centro Neurolesi Bonino-Pulejo in Messina will be evaluated.

All patients will undergo clinical, neuropsychological and psychological evaluation at the beginning (baseline T0), at the end (T1) and after ... months from the end of treatment (follow up T2).

Eligibility

Inclusion Criteria:

For MCI patients:

        Patients aged between 18 and 80 years; Clinical and instrumental diagnosis of MCI,
        according to the normal clinical practice adopted; Written informed consent obtained from
        the patient;
        For Metabolic patients:
        Age: >18 years BMI > 30 kg/m²
        Willingness to follow requests as per protocol, including:
        Signing an informed consent. Participation in scheduled follow-up visits. Carrying out
        instrumental and laboratory tests
        Exclusion Criteria:
        For MCI patients:
        age under 40 other concomitant neurological and/or psychiatric condition drug abuse
        unstable clinical conditions requiring acute hospitalization.
        For Metabolic patients:
        unstable clinical conditions requiring acute hospitalization. associated serious
        pathologies and/or with reduced life expectancy, including renal failure under dialysis
        treatment, liver cirrhosis, malignant neoplasms, NYHA class III-IV heart failure, chronic
        respiratory failure under oxygen therapy.
        psychological or psychiatric conditions that may reduce study cooperation.

Study details

Dementia, Mild Cognitive Impairment

NCT06227364

IRCCS Centro Neurolesi "Bonino-Pulejo"

29 January 2024

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