Overview
The aim of this study is to determine the clinical spectrum and natural progression of Hereditary Spastic Paraplegias(HSP) and related disorders in a prospective multicenter natural history study, to assess the clinical, genetic and epigenetic features of patients with Spastic Paraplegias to optimize clinicalmanagement..
Eligibility
Inclusion Criteria:
- Patients with the clinical diagnosis of spastic paraplegia
- Clinical diagnosis of patients with spastic paraplegia
- Unrelated healthy controls
Exclusion Criteria:
- Decline to participate.
- There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.