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Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

Recruiting
18-99 years
All
Phase 2
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  • Simplified (AI rewritten)

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Overview

To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and protein drugs into advanced solid tumors.

Description

Drug-eluting microspheres such as DC-beads will be loaded with IL2, PD1/PDL1/CTLA4 antibody, or /and VEGF/VEGFR antibody with or without doxorubicin/idarubicin for various time and injected into tumors under CT guidance. Side effects and treatment efficacy after injection of drug-eluting microspheres into malignant tumors will be assessed according to RICEST1.1 standard.

Eligibility

Inclusion Criteria:

  • Solid advanced malignant tumors
  • Age between18 and 99 years
  • Life expectancy is greater than three months

Exclusion Criteria:

  • Benign tumor
  • Life expectancy is less than three months
  • Serious medical comorbidity
  • Others

Study details
    Hepatocellular Carcinoma
    Solid Tumor
    Adult

NCT04770207

Second Affiliated Hospital of Guangzhou Medical University

28 January 2024

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