Overview

Evaluate whether the combination of Rezvilutamide and androgen deprivation therapy (ADT) with docetaxel improves overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) compared to the combination of Rezvilutamide and ADT.

Eligibility

Inclusion Criteria:

1. Males aged ≥40 years and ≤80 years.
2. Histologically or cytologically confirmed prostate adenocarcinoma.
3. Metastatic disease.
4. Eligible for ADT and Docetaxel.
5. Started or not started first-generation androgen deprivation therapy (ADT), but not exceeding 12 weeks before randomization.
6. ECOG score of 0 or 1.
7. Laboratory tests meet the following requirements:
   • Hematology: neutrophils ≥1.5×10^9/L, platelets ≥100×10^9/L, hemoglobin ≥9g/dL.
   • Renal function: serum creatinine ≤1.5× upper limit of normal (ULN).
   • Liver function: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5× ULN, total bilirubin (TBIL) ≤1.5× ULN.
   • Coagulation function: international normalized ratio (INR) <1.5.
8. Study subjects: Patients with mHSPC have a confirmed pathology of prostate

   adenocarcinoma with high tumor burden, which is defined by having at least one of the following conditions:

   1. Bone scan showing ≥4 bone metastatic lesions (with at least one site outside the pelvis or spine).
   2. CT/MRI revealing visceral metastatic lesions (excluding lymph nodes).

Exclusion Criteria:

        Patients who meet any of the following criteria are not eligible to participate in this
        study:
          1. Prior use of LHRH agonists/antagonists; second-generation androgen receptor (AR)
             inhibitors such as enzalutamide, ARN-509, darolutamide (ODM-201), or other
             investigational AR inhibitors; CYP17 enzyme inhibitors such as abiraterone acetate or
             oral ketoconazole for anti-tumor treatment of prostate cancer; chemotherapy or
             immunotherapy for prostate cancer prior to randomization.
          2. Received radiation therapy/radiopharmaceutical treatment within 2 weeks before
             randomization.
          3. Any of the following conditions within 6 months before randomization: stroke,
             myocardial infarction, severe/unstable angina pectoris, coronary artery/peripheral
             artery bypass surgery, congestive heart failure (New York Heart Association class III
             or IV).
          4. Previous malignancy, except adequately treated basal cell carcinoma or squamous cell
             carcinoma of the skin or superficial bladder cancer not invading the deeper muscle
             layer (i.e., pTis, pTa, and pT1) and any other cancer in complete remission for at
             least 5 years before randomization.
          5. Gastrointestinal diseases or procedures that are expected to significantly interfere
             with the absorption of study treatment.
          6. Inability to take oral medication.