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The Efficacy and Safety of PEGylated GH for the Treatment of Short Stature in Chinese Children-GLOBE Reg

The Efficacy and Safety of PEGylated GH for the Treatment of Short Stature in Chinese Children-GLOBE Reg

Recruiting
14-18 years
All
Phase N/A

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Overview

In order to further observe the long-term safety and effectiveness of real-world polyethylene glycol-recombinant human growth hormone(PEG-rhGH) treatment of GHD, idiopathic short stature, and SGA in children, explore and analyze the factors affecting the efficacy of PEG-rhGH and the height prediction model after treatment, etc., collect and analyze more scientifically and rationally, and understand the situation of real-world PEG-GH treatment. A database registration study was developed.

Description

A database registration study was developed to retrospectively analyze the efficacy and safety of polyethylene glycol recombinant human growth hormone injection in the treatment of slow growth in children caused by endogenous growth hormone deficiency, idiopathic short stature, Turner syndrome, etc., and to further prospectively follow up and monitor. In order to participate in the global real-world use of long-acting growth hormone, all data from this study were uploaded to the Global Registry of New Therapies for Rare Endocrine Diseases and Bone Disorders (GloBE-Reg) platform.

Eligibility

Inclusion Criteria:

        Patients with endogenous growth hormone deficiency, Turner Syndrome, SGA, idiopathic short
        stature, etc. treated with polyethylene glycol recombinant human growth hormone injection
        Exclusion Criteria:
        Patients with serious heart and lung, blood system, malignant tumors and other diseases or
        systemic infections, immune function is low and Persons with mental illness;

Study details
    Growth Hormone Treatment
    Growth Disorders

NCT06037473

Beijing Children's Hospital

28 January 2024

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