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Microwave Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms

Microwave Ablation for Treatment of Small Renal Tumors and Primary and Secondary Liver Neoplasms

Recruiting
18 years and older
All
Phase N/A

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Overview

The goal of this observational study is to collect data on efficacy and safety of microwave ablation (MWA) used to treat subjects with primary and secondary liver malignancies and renal malignancies. The main question it aims to evaluate the short, medium and long-term clinical course of patients treated with MWA.

Participants will not alter their normal clinical and therapeutic practice, due to the observational nature of the study, and all data regarding microwave treatments will be collected (including demographic data). follow their normal clinical and therapeutic path

Description

Observational, retrospective and prospective, monocentric study. The objective is to evaluate the short, medium and long-term clinical course of patients undergoing microwave ablation (MWA) for small renal tumors and primary and secondary liver neoplasms. Evaluation of clinical efficacy (progression free survival),safety and technical outcome of microwave ablation as well as clinical outcome of the procedure will be evaluated.At the end of the follow-up periods, the data collected will be compared with those available in the literature on MWA, cryoablation (CA), radiofrequency ablation (RFA) and surgical resection.

Eligibility

Inclusion Criteria:

  • > 18 years with primary or secondary liver tumors or small kidney tumors that are not candidates for surgery or cannot be radically resected by surgery alone
  • Primary liver cancer: up to three liver nodules ≤ 3 cm
  • Secondary hepatic tumours: up to nodules ≤ 3 cm provided that the objective is complete hepatic clearance Renal tumours: single or multiple (von Hippel Lindau syndrome), < 4 cm

Exclusion Criteria:

  • pregnant women
  • non-manageable coagulopathies
  • Extended extrahepatic or extrarenal disease
  • for liver ablation: presence of bilio-digestive anastomosis

Study details
    Liver Cancer
    Liver Metastasis Colon Cancer
    Kidney Cancer
    Renal Cell Carcinoma

NCT03981497

Francesco De Cobelli

28 January 2024

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