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Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease

Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease

Recruiting
18-75 years
All
Phase 2
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Overview

Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and aggregation of Lewy bodies in neurons. Although aging, oxidative damage and neuroinflammation have been recognized to play crucial roles in the pathogenesis of PD, the precise etiology remains obscure. Emerging evidence suggests PD is a systemic metabolic disease, and metabolic abnormality correlates with functional alternations in PD

Eligibility

Inclusion Criteria: 

        Age ≥ 18 years Both males and females will be included Negative pregnancy test and
        effective contraception. Diagnosed Parkinson's disease patient taking Levodopa
        Exclusion Criteria:
        Secondary causes of Parkinsonism Diabetic patients Patients taking anti-inflammatory drugs
        Atypical parkinsonian syndromes Prior stereotaxic surgery for Parkinson's disease Pregnancy
        and lactation Suffering from active malignancy Addiction to alcohol and/or drugs Known
        allergy to the studied medications

Study details
    Parkinson Disease

NCT05781711

Tanta University

4 May 2024

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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