Overview

We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.

Eligibility

Inclusion Criteria:

        Group I includes healthy subjects with normal appearing corneas, normal topography and
        pachymetry. Group II includes patients diagnosed as having mild, moderate or advanced
        keratoconus by our ophthalmology expert on the basis of topography and pachymetry. Group
        III includes healthy subjects who have undergone LASIK surgery in the past 12 months
        without complications. Inclusion criteria include normal post-operative topography and
        pachymetry. Group IV includes patients (age 20 - 60) who have undergone LASIK surgery at
        least 12 months before the study imaging and have been diagnosed with post-LASIK ectasia
        based on topography, pachymetry and clinical evaluation.Patients diagnosed with
        keratoconus. Group V- Volunteers to receive PRK surgery This group includes patients who
        have been diagnosed with myopia and have been scheduled to undergo PRK surgery. Patients
        with high astigmatism > 2 diopter, prior ocular surgeries, and those patients taking any
        ocular medications except seasonal allergy medicine such as ketotifen or artificial tears
        will be excluded. Group VI-Volunteers to receive LASIK Surgery This group includes myopic
        patients who are scheduled to receive LASIK surgery. Patients with high astigmatism > 2
        diopter, prior ocular surgeries, and those patients taking any ocular medications except
        seasonal allergy medicine such as ketotifen and artificial tears will be excluded. Group
        VII- Patients with Fuch's Endothelial Corneal Dystrophy. This group includes subjects who
        are diagnosed with Fuch's corneal dystrophy, at early, mild and advanced stages. The
        inclusion also extends to subjects with, and without keratoconus. But this exclude patients
        with any other corneal disorders other than keratoconus, and/or history of ophthalmological
        surgeries that may affect endothelium cell status, e.g. cataract surgeries.
        Overall Exclusion Criteria for all groups: Volunteers who
          -  Have occludable narrow angles (without a patent peripheral iridotomy)
          -  Monocular subjects
          -  Do not or cannot understand the instructions for the imaging