Overview

Four-part study of the safety, tolerability and pharmacokinetics of 3 forms of TR-01-XRR, 1 form of TR-01-XRS, and 1 form of TR-01-XR in healthy adults.

Eligibility

Inclusion Criteria:

• BMI between 18 and 32 kg/m2
• Medically healthy without clinically significant or relevant medical history

Exclusion Criteria:

• Evidence of recurrent disease, physical illness or medical condition that could affect action, absorption or disposition of investigational products
• Use of any prescription or over-the-counter medication that cannot be discontinued for the duration of the study
• Impaired renal function
• Cardiac abnormalities
• Positive HIV, HBsAg or HCV
• Positive test for alcohol, drugs of abuse or cotinine