Overview
The primary aim of this study is to investigate the effect of 5-fluorouracil, imiquimod, and melatonin for actinic keratosis on immunological gene, and protein expressions profiles. Secondarily, the aim is to assess the effect of the treatment on the histopathology of actinic keratoses.
Eligibility
Inclusion Criteria:
- Participants should have a clinical diagnosis of actinic keratosis
- Participants should be 18 years old or above
- Participants must sign an informed consent
Exclusion Criteria:
- Known allergic reaction to either 5-fluorouracil , imiquimod, or melatonin
- Immunomodulating treatment
- Predictable poor compliance (due to i.e. dementia, substance abuse, psychiatric disease, life-threatening disease or language barriers)
- Pregnant or breastfeeding
- Females not in menopause (defined as no menstruation during the last 12 months) should use a secure birth control (intrauterine devices, hormonal contraceptives including - oral pills, patches, vaginal rings and injections) during the entire period of the trial