Overview

The goal of this observational study is to test the feasibility of intracoronary adenosine administration during coronary flow reserve(CFR) and index of microcirculatory resistance(IMR) assessment in a population with angina. The main questions it aims to answer

are

• Repeatability of CFR and IMR assessment while hyperemia with intracoronary adenosine was administered.
• Evaluate the correlation of the intrinsic signal of coronary waveform versus physiologic ischemia, while defined by fractional flow reserve(FFR) and CFR respectively.
• The predictive value of FFR, CFR, and IMR on major adverse cardiovascular outcomes in 3 years Participants will undergo FFR, CFR, and IMR assessments in the catheterization laboratory of the National Taiwan University Hospital Hsin-Chu Branch, then clinical events follow up for 3 years.

Eligibility

Inclusion Criteria:

• Participants with angina

Exclusion Criteria:

• Severe valvular heart disease
• History of asthma
• Heart rate less than 50 beats per minute
• systolic blood pressure less than 90 mmHg