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Clinical Applicability of pCASL as a Substitute for FDG-PET in MCI and SCD Patients

Clinical Applicability of pCASL as a Substitute for FDG-PET in MCI and SCD Patients

Recruiting
18-80 years
All
Phase N/A
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Overview

The goal of this observational study is to compare cerebral perfusion patterns with pseudo-continuous arterial spin labeling (pCASL) and brain metabolism patterns with fluorodeoxyglucose-position emission tomography (FDG-PET) in patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). The main questions it aims to answer

are
  • Do pCASL sequences identify hypoperfusion patterns that correlate well with FDG-PET hypometabolic patterns?
  • Are there differences in this correlation in terms of cerebrospinal fluid (CSF) profiles?
  • Can hypoperfusion patterns in pCASL predict conversion to dementia? Participants will undergo brain 3 Tesla magnetic resonance imaging (MRI), FDG-PET, lumbal puncture and blood collection to analyze amyloid beta and tau, yearly detailed neuropsychological tests for three years.

Eligibility

Inclusion Criteria:

  • Patients with mild cognitive impairment or subjective cognitive decline according to established criteria
  • Clinical Dementia Rating scale of 0 or 0.5
  • Signed informed consent before study entry

Exclusion Criteria:

  • Contraindication to brain MRI, FDG-PET or lumbar puncture
  • Secondary causes of cognitive decline
  • Known major neurological or psychiatric comorbidities
  • History of substance or alcohol abuse
  • Known causes of cerebral brain perfusion alterations
  • Enrollment in anti-amyloid or anti-tau drugs trials

Study details
    Mild Cognitive Impairment
    Subjective Cognitive Decline

NCT05756270

University of Milano Bicocca

28 January 2024

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