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Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis

Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis

Recruiting
18 years and older
All
Phase 4
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

The study aims to investigate the olfactory TDI score (Threshold, Discrimination, Identification) using the Sniffin' sticks test for patients with chronic rhinosinusitis with nasal polyps (CRSwNP) on dupilumab. Twenty-seven adult patients will be followed up during the treatment with dupilumab on three visits to the Otolaryngology Clinic (Baseline, 3 months and 6 months).

The primary endpoint will be the TDI score. Nasal polyp score, Quality of Olfactory Disorders

  • negative symptoms (QOD-NS symptom scores), SNOT-22 will be secondary endpoints.

Eligibility

Inclusion Criteria:

  • Patients older than 18 years old
  • Chronic rhinosinusitis with Nasal Polyps
  • Olfactory loss
  • Clinical indication for treatment with Dupilumab

Exclusion Criteria:

Patients with olfactory loss from other causes such as:

  • Sinonasal malignancies
  • Trauma
  • Idiopathic olfactory loss
  • Use of cocaine
  • COVID-19 related olfactory loss
  • Pregnancy

Study details
    Chronic Rhinosinusitis With Nasal Polyps
    Olfactory Disorder

NCT04869436

Lawson Health Research Institute

18 April 2024

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