Overview
This study is designed to investigate whether adjuvant radiochemotherapy after incomplete resection has a better survival than adjuvant radiotherapy for thymoma or thymic carcinoma.
Description
The previous trials have showed that radiotherapy was significantly associated with prolonged OS and chemotherapy is playing an increasing role in treatment of patients with thymoma or thymic carcinoma.However,whether patients with thymoma or thymic carcinoma could benefit from adjuvant radiochemotherapy after incomplete resection remains controversial. The purpose of this study is to investigate whether adjuvant radiochemotherapy after incomplete resection can improve survival for thymoma or thymic carcinoma.
Eligibility
Inclusion Criteria:
18~75 years old; Eastern Cooperative Oncology Group performance status of 0 to 2;
Pathologically confirmed ; incomplete resection (R1 or R2);have adequate bone marrow,
hepatic, and renal function;Patients receive incomplete resection within 3 months; Written
informed consent.
Exclusion Criteria:
Patients with distant metastases; Patients underwent radiotherapy or chemotherapy; Patients
who have malignancy history excluding carcinoma in situ of cervix in the previous five
years; Active clinical pulmonary infection; Pregnant or nursing.