Overview
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
Description
In case the study will show that the live birth rate in single euploid NC frozen embryo transfer cycles without LPS is not inferior to NC cycles with LPS, treatment can be simplified, and participants comfort can be increased.
Eligibility
Inclusion Criteria:
- Age: 18 to 40 years
- Regular ovulatory cycles
- Availability of at least one euploid embryo after Trophectoderm biopsy for PGT-A on day 5 or day 6
- Detection of ovulation by P4 rise > 1.0 ng/ml after LH surge
- P4 value of at least 5 ng/ml on day 4 after ovulation
Exclusion Criteria:
- History of repeated pre-menstrual spotting
- Factors affecting the implantation through anatomical changes of the uterus / ovaries or the tubes (adenomyosis, Asherman syndrome, endometriosis, uterine fibroids / polyps, isthmocele with intracavitary fluid presence, hydrosalpinx….)