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Exocrine Pancreatic Insufficiency's Prevalence in Active Crohn's Disease

Exocrine Pancreatic Insufficiency's Prevalence in Active Crohn's Disease

Recruiting
18 years and older
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

This study aims to assess the prevalence of exocrine pancreatic insufficiency (EPI) in a population of patients with active Crohn's disease. Studies already describe a prevalence rate around 18-66%. In this multicentric prospective study, we plan to compare EPI's prevalence at week 0 and week 14 of an induction phase of a biological therapy. The biological therapy will be initiate for an active Crohn's disease. Secondary outcomes will be: malnutrition's prevalence, and Crohn's disease activity level.

Eligibility

Inclusion Criteria:

  • Age of 18 years or more
  • Crohn's disease diagnosed for more than 3 months.
  • Active Crohn's disease : CDAI score > 150 + [CRP > 5 mg/L or faecal calprotectin > 250mcg/g or endoscopic lesion or MRI lesion]
  • Indication of a biological therapy (anti-TNFα, vedolizumab ou ustekinumab).

Exclusion Criteria:

  • Crohn's disease that doesn't fit the previous criteria
  • Extended resection of small intestine (>40cm)
  • Chronic pancreatitis diagnosed before inclusion
  • Contraindication to biological therapy (anti-TNFα, vedolizumab ou ustekinumab)
  • Pancreatic enzyme replacement therapy
  • Pregnant or breastfeeding woman
  • Patient under the protection of a conservator

Study details
    Crohn Disease

NCT03915262

Hospices Civils de Lyon

28 January 2024

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