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The Effect of PERT on Patients Undergoing Pancreaticoduodenectomy

The Effect of PERT on Patients Undergoing Pancreaticoduodenectomy

Not Recruiting
18-80 years
All
Phase 4

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Overview

A comprehensive perioperative nutrition management plan for pancreaticoduodenectomy, primarily based on pancreatic enzyme replacement therapy (PERT). A prospective randomized controlled study was conducted to comprehensively analyze the perioperative nutritional status of patients undergoing pancreaticoduodenectomy, with the aim of exploring:

  1. The effect of PERT on postoperative complications and physiological status after pancreaticoduodenectomy;
  2. The efficacy of PERT treatment on clinical symptoms, nutritional indicators, and quality of life (QOL) related to pancreatic exocrine dysfunction (PEI) after pancreaticoduodenectomy;
  3. The personalized full process nutrition management strategies based on risk factor stratification.

Eligibility

Inclusion Criteria:

  • Gender unlimited, 18-80 years old;
  • Patients undergoing pancreaticoduodenectomy due to various benign or malignant diseases;
  • Voluntary testing with informed consent.

Exclusion Criteria:

  • Pregnant women and lactating women
  • Patients with distant metastasis based on tumor staging before surgery;
  • Tumor recurrence;
  • Refuse to sign the consent form.

Study details
    Pancreatic Exocrine Insufficiency
    Pancreatic Enzyme Replacement Therapy
    Pancreaticoduodenectomy

NCT06119880

Ruijin Hospital

30 January 2026

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