Overview
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total occlusion (CTO) compared with non-diabetic patients with CTO. This retrospective cohort enrolls consecutive T2DM patients who had at least one lesion with coronary angiographic total occlusion.
Description
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion (COLLECT) study is a single center, retrospective cohort study to investigate potential factors associated with the development of coronary collateral circulation in diabetic patients. Investigators will consecutively enroll T2DM patients who had at least one lesion with coronary angiographic total occlusion. The development of coronary collateral circulation will be graded according to the Rentrop method and patients will be divided into poor CCC (grade 0 or 1) or good (grade 2 or 3) CCC groups according to their Rentrop grades. Baseline clinical and laboratory characteristics at hospital admission will be recorded to analyze potential factors associated with the development of coronary collateral circulation in T2DM patients with CTO. Later, their cardiac function will be evaluated by echocardiography at one year follow-up.
Eligibility
Inclusion Criteria:
- Age 18-90 years
- Type 2 diabetes diagnosed by one of the following criteria:
HbA1c >/= 6.5% Fasting plasma glucose >/= 7.0 mmol/l (confirmed) 2h plasma glucose value
during OGTT >/= 11.1 mmol/l Already receiving glucose-lowering agents.
- At least one lesion with angiographic total occlusion
Exclusion Criteria:
- eGFR<15mL/(min·1.73m2)
- chronic heart failure with NYHA grade ≥3
- had a history of coronary artery bypass grafting
- had received a percutaneous coronary intervention within the prior 3 months
- Malignant tumor or immune system disorders
- Pulmonary heart disease