Overview
This prospective, randomized, double-blind clinical trial will be carried out Conservative Dentistry, Faculty of Dentistry, Jamia Millia Islamia. Seventy adult patients (35 alcoholic and 35 non-alcoholics) with symptomatic irreversible pulpits in a mandibular first or second molar will receive an IANB with 2% lidocaine. In case of pain during treatment, the procedure will be stopped, and the patients will be asked to rate the pain on the Heft-Parker scale. The injection shall be considered as successful if the patient reports pain scores less than 55 on the HP scale.
Eligibility
Inclusion Criteria:
- Symptomatic carious exposed mandibular first or second molars.
- Alcoholic patients: Patient with low-moderate drinking levels according to the US National Institute on Alcohol Abuse and Alcoholism
- Control patients: No history of alcohol consumption
- Positive and prolonged response to thermal sensitivity tests and electric pulp test.
- Vital coronal pulp on access cavity preparation.
- American Society of Anesthesiologists class I or II medical history.
- Ability to understand the use of pain scales.
Exclusion Criteria:
- Active pain in more than 1 teeth
- Teeth with fused roots.
- Radiographic evidence of an extra root.
- Large restorations with overhanging margins.
- Full crowns or deep periodontal pockets.
- Hypertension or cardiovascular diseases, compromised immunity, active infection or inflammation
- Known allergy or contraindications to any content of the local anesthetic solution or non-steroidal anti-inflammatory drugs (NSAIDs)
- History of known or suspected drug abuse.
- Taking any drugs which could affect the pain perception, e.g, opioids, antidepressants, anticonvulsants, muscle relaxants, anxiolytics, sedatives, nsaids. 23
- Pregnant or breastfeeding patients.
- Patients with asthma, gastric ulcers, bleeding disorders.