Overview
This is a prospective, single-blinded, multicenter study evaluating the benefit of sinonasal irrigations following endoscopic pituitary surgery. The goal of this study is to create practice changing guidelines with objective data highlighting the importance of irrigations on postoperative outcomes for pituitary surgery.
Description
This prospective study, coupled with the results of the recent POET study evaluating the role of antibiotics in postoperative outcomes for pituitary surgery, will guide physicians in the optimal management of patients following endoscopic pituitary surgery.
The investigator group has an established record of completing multicenter studies (e.g., POET, TRANSPHER) that have influenced clinical practice guidelines, raised the profile of Barrow in the pituitary and skull base community, and resulted in numerous peer-reviewed publications and awards.
Eligibility
Inclusion criteria
- Adult patient undergoing endoscopic surgery for resection of pituitary tumors
- nonfunctioning adenoma
- acromegaly
- prolactinoma
- Rathke's cleft cyst
- Adults >18 and <85 years of age
- English speaking and able to understand the ASK Nasal-12 and SNOT-22 scales
- Free of any physical, mental, or medical condition which, in the opinion of the investigator, makes study participation inadvisable
- Planned binostril surgical approach
- Either with or without septal flap reconstruction
- Either with or without septoplasty
Exclusion criteria
- Active sinus infection
- Allergic rhinitis
- Asthma
- Vascular or inflammatory disease
- History of previous sinonasal surgery
- Any subject who is unwilling or unable to sign informed consent for the study
- Pregnancy
- Incarcerated patients
- Cushing's disease
- History of chronic sinusitis
- Extended approaches to the skull base
- Active sinusitis
- Nasal polyps
- Concurrent antibiotics for another indication (i.e., urinary tract infection)
- Immunodeficiency
- History of radiation to the skull base