Image

SBRT Versus Ablation for Perivascular Hepatocellular Carcinoma

SBRT Versus Ablation for Perivascular Hepatocellular Carcinoma

Not Recruiting
18-75 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

Powered by AI

Overview

This trial is a multi-center, phase III, randomized (1:1) clinical trial. The aim is to explore the efficacy and safety of SBRT for perivascular hepatocellular carcinoma, compared with RFA.

Description

The primary endpoint is 1-year local recurrence rate and disease-free survival. We planned to recruit 170 patients who diagnosed as perivascular hepatocellular carcinoma. The patients will be randomized into SBRT group and RFA group as 1:1 ratio.

Eligibility

Inclusion Criteria:

  1. Primary hepatocellular carcinoma or recurrent hepatocellular carcinoma after curative treatment.
  2. Unifocal tumor ≤5cm
  3. Closed to great vessels (diameter ≥3mm)
  4. ECOG score 0-1
  5. Child-Pugh grade A or B7
  6. Sufficient liver and kidney function

Exclusion Criteria:

  1. Vascular invasion
  2. Extra-hepatic metastasis
  3. Received TACE before
  4. Inflammation of local skin
  5. Dysfunction of liver, kidney or bone marrow.
  6. Concomitant other malignant tumor or HIV infection

Study details
    Hepatocellular Carcinoma

NCT04434989

Sun Yat-sen University

30 January 2026

Contact a study center

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.