Overview
The aim of the study is to evaluate the impact of early nutrition on gut health in children. A prospective cohort of newborns will be recruited at birth and followed up to 4 years of age. Information on parent's nutritional habits and life style, breastfeeding duration and child's complementary feeding, will be collected. Cord blood cells and stools will be collected at birth, 6 months, 2 years and 4 years of age for implementing a biological collection. Gut health will be evaluated in children during the first four years of life based on fecal secretory immunoglobulin A (SIgA) and presence of digestive symptoms. Precise data on breastfeeding practices and their short- and medium-term effects on the health of the child, in particular and in an innovative way on gut health, will be obtained.
Eligibility
Inclusion Criteria:
For the mother:
- Pregnant woman (>18 years old) followed at the Lille University Jeanne de Flandres Maternity
- Woman who can speak, read and write in French
- Single pregnancy
- Informed consent
- Living in the Lille area
For the father:
- Men >18 years old
- Informed consent
Exclusion Criteria:
For the mother:
- Impossibility to participate to the study follow-up
- Woman under guardianship or curatorship
- Woman involved in another study inconsistent with biological samples collection
For the child after birth:
- Prematurity <37 weeks
- Impossibility to participate to the study follow-up
- Child under judicial protection measure
- Child involved in another study inconsistent with biological samples collection