Overview
The aim of the study is to
- To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively.
- To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes
- To investigate if non-oxidized PTH reflects bone turnover
Description
Patients with reduced renal function and suspected high turnover or low turnover bone disease are recruited.
A bone biopsy and a 18F-PET scan are performed and it is investigated if the 18F-PET can discriminate high turnover from low turnover bone disease
Eligibility
Patients with reduced renal function:
Inclusion Criteria:
-≥ 18 years
- estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml/min/1,73m2
- PTH < 150 pg/ml or PTH > 300 pg/ml
Exclusion Criteria:
- ongoing malignancy
- Allergy towards tetracyclin
- Pregnancy
Control Group:
Inclusion Criteria:
-≥ 18 years
- eGFR >= 60 ml/min
- under examination for c prostata
- Prostatic Specific Antigen (PSA) total <40 µg/l
- Exclusion
- Former kidney disease
- ionized calcium or PTH outside normal range
- Known metabolic bone disease
- treatment with anticoagulants
- Disturbed thrombosis and hemostasis