Overview
Currently available medications for PCOS are symptom(s) oriented but have limitations because of its complex pathophysiology. The most preferred drug against PCOS is metformin which act as an insulin sensitizer to improve insulin-glucose metabolism and anovulatory cycles in PCOS. However, its use is associated with various side effects such as bloating, diarrhea and nausea. Thus, it is imperative to explore various other alternatives to combat this gynecological problem.
Description
Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in reproductive age women, with a prevalence between 5%-15%. Currently, sedentary lifestyle, excessive intake of junk food and increasing prevalence of obesity has been associated with rise in the incidence of PCOS.
Eligibility
Inclusion criteria No complications record of reproductive system, 4) PCOS diagnosed using
Rotterdam criteria fulfilling any two of the following: (i) Menstrual irregularity or
oligo-/anovulation, (ii) Hyperandrogenism (clinically and/or biochemically), (iii)
Polycystic appearance on ultrasound
Exclusion criteria
1) Patients with severe adverse drug reactions, 2) Record of cardiovascular, diabetes,
hepatic and neoplastic disorders or other concurrent medical illnesses, 3) Hormonal
contraceptive used within 6 months, or anti-obesity drugs within 3 months of the study, 4)
Irregular menstrual bleeding other than PCOS and 5) Positive pregnancy test.