Overview
Determine the effect of high-dose pancreatic enzyme supplementation on nutritional indicators and clinical course in critically ill patients undergoing enteral nutrition.
Eligibility
Inclusion Criteria:
- Adults 19 years and older
- Hospitalized in the surgical/medical intensive care unit of the Seoul National University Hospital
- Enteral nutrition
- Patients who consented to this study
- Patients with risk factors for pancreatic exocrine dysfunction
- Shock (Norepinephrine)
- Sepsis (3 rd definition of sepsis)
- Diabetes
- Cardiac arrest
- hyperlactatemia serum lactate > 2 mmol/L)
- Mechanical ventilation
- Continuous renal replacement therapy
Exclusion Criteria:
- chronic pancreatitis
- unresectable pancreatic cancer
- History of pancreatectomy
- Underlying diseases in which the effect of Exocrine pancreatic enzyme administration
is difficult to show
- Inflammatory bowel disease
- Short bowel syndrome