Overview

The goal of this project is to see if two new potential treatments (defactinib and the combination tablet of decitabine/cedazuridine) can safely be combined to improve outcomes in people with high-risk myelodysplastic syndrome (MDS), certain forms of Acute Myeloid Leukaemia (AML), and Chronic Myelomonocytic Leukaemia (CMML). Decitabine/cedazuridine is approved for use by the Australian Therapeutics Goods Administration (TGA) as treatment for MDS. Defactinib is an experimental treatment. This means it is not an approved treatment for MDS in Australia. So far it has been given to over 625 patients in studies across the world.

All study participants will receive active treatment, there is no placebo. Participants will take the decitabine/cedazuridine treatment once a day for 5 days in a row (day 1 to day 5) on its own for the first month (cycle). From month 2 participants will take the decitabine/cedazuridine treatment and will also take the defactinib treatment, both for 5 days in a row on days 1 to day 5 each month (cycle). Defactinib is taken twice a day.

Eligibility

Inclusion Criteria:

Participants must meet all of the following criteria at the time of screening:

1. Age ≥ 18 years
2. Documented diagnosis of:
   1. Myelodysplastic syndrome (MDS) classified as intermediate-2 or high risk according to the International Prognostic Scoring System (IPSS), or
   2. Acute Myeloid Leukaemia (AML) with 20-30% marrow blasts and multilineage dysplasia, according to WHO classification, or
   3. Chronic myelomonocytic leukemia (CMML) with 10-29% marrow blasts without myeloproliferative disorder according to World Health Organisation (WHO) classification. This confirmation will be from either the Bone marrow aspirate (BMA) performed at screening or a standard of care BMA if performed up to 6 weeks before cycle 1 day 1.
3. Performance status by Eastern Cooperative Oncology Group (ECOG) Criteria of 0 or 1
4. Unsuitable for allogeneic stem cell transplantation
5. For participants who were born female who are of childbearing potential (FCBP) the following criteria apply:
   1. Agreement to use at least two highly effective (per Clinical Trial Facilitation Group) contraceptive methods throughout the study, and for 6 months following the last dose of study drug:
      • Oral/intravaginal/transdermal combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation
      • Oral/injectable/implantable progestogen-only hormonal contraception associated with inhibition of ovulation
      • Intrauterine device (IUD)
      • Intrauterine hormone-releasing system (IUS)
      • Bilateral tubal occlusion
      • Vasectomised partner
      • Sexual abstinence and
   2. Confirmation of a negative serum pregnancy test at screening.
6. Male participants with a partner who was born female and is of childbearing potential

   must agree to use at least two highly effective (per Clinical Trial Facilitation Group) contraceptive methods throughout the course of the study and for 6 months following the last dose of study drug, and refrain from donating sperm during the same period

7. Provision of signed written informed consent document prior to any study related assessments or procedures being carried out.

Exclusion Criteria:

        Participants who meet any of the following criteria at the time of screening/enrolment (up
        to 28 days prior to Cycle 1 Day 1) will be ineligible for entry into the study:
          1. Acute myeloid leukemia (AML) with ≥ 30% blasts in bone marrow according to WHO
             classification.
          2. Prior allogeneic or autologous stem cell transplant.
          3. Prior receipt of >1 cycle of a hypomethylating agent.
          4. Clinical evidence of central nervous system (CNS) or pulmonary leukostasis,
             disseminated intravascular coagulation, or CNS leukemia.
          5. Use of any of the following within 28 days prior to cycle 1 day 1:
               1. thrombopoiesis-stimulating agents ([TSAs]; eg, Romiplostim, Eltrombopag,
                  Interleukin-11)
               2. ESAs (Erythropoiesis stimulating agent) and other RBC (Red blood cell)
                  hematopoietic growth factors (eg, interleukin-3)
               3. Any other investigational medicinal product from another clinical trial.
          6. Exposure to any medication, supplement, traditional/herbal medicine, or food with
             potential for drug-drug interactions with defactinib during the course of the study.
             This includes:
               1. strong CYP3A4 inhibitors or inducers
               2. strong CYP2C9 inhibitors or inducers
               3. P-glycoprotein (P-gp) inhibitors or inducers
          7. Treatment with warfarin. Patients on warfarin can be converted to low molecular-weight
             heparin or direct oral anticoagulants (DOACs). Participants unwilling or unable to
             convert to an alternative are not eligible.
          8. Use of hydrea for more than 7 days prior to cycle 1 day 1. Use within that time period
             is permissible.
          9. Concurrent use of corticosteroids unless the participant is on a dose of ≤10mg
             prednisolone or equivalent for medical conditions other than MDS.
         10. Active inflammatory bowel disease, or any other gastrointestinal disorder or defect
             that would interfere with the ingestion, absorption, distribution, metabolism or
             excretion of the investigational products and/or predispose the participant to an
             increased risk of gastrointestinal toxicity.
         11. Prior history of malignancies, other than MDS unless the participant has been free of
             the disease for ≥ 12 months. However, participants with the following
             history/concurrent conditions are allowed:
               1. Basal or squamous cell carcinoma of the skin
               2. Carcinoma in situ of the cervix
               3. Carcinoma in situ of the breast
               4. Incidental histologic finding of prostate cancer (T1a or T1b using the tumor,
                  nodes, metastasis [TNM] clinical staging system)
         12. Significant active cardiac disease within the previous 6 months, including:
               1. New York Heart Association (NYHA) class III or IV congestive heart failure;
               2. Unstable angina or angina requiring surgical or medical intervention; and/or
               3. Myocardial infarction
         13. Baseline Qt interval greater than 440 milliseconds (males) or 450 milliseconds
             (females)
         14. Active systemic infection:
               1. Infection with ongoing signs/symptoms related to the infection without
                  improvement despite appropriate anti- infectives
               2. Active Hepatitis B (HBV) infection (defined as HBsAg positive, or HBcAb positive
                  and measurable HBV DNA; participants who are HBcAb positive must have HBV DNA
                  assayed during screening)
               3. Participants with Human Immunodeficiency Virus (HIV) or Hepatitis C (HCV)
                  infection will be considered individually by the coordinating principal
                  investigator:
                    -  Those with HIV will generally be eligible if receiving antiretroviral
                       therapy, HIV viral load (VL) is suppressed <50 copies/mL , and CD4≥350
                       cells/mm3.
                    -  Those with HCV will generally be eligible if there is no evidence of
                       clinical hepatic dysfunction or other systemic manifestations of HCV disease
                       and the hepatic parameters below are met. Consideration should be given to
                       curative HCV therapy prior to enrollment in consultation with HCV clinician,
                       if possible.
         15. Any of the following laboratory abnormalities:
               1. Serum AST/SGOT (Aspartate transaminase / Serum glutamic oxaloacetic transaminase)
                  or ALT/SGPT (Alanine aminotransaminase / Serum glutamic pyruvate transaminase) >
                  2.5 x ULN (upper limit of normal)
               2. Serum total bilirubin > 1.5 x ULN. Patients with Gilbert syndrome may enroll if
                  total bilirubin < 51 umol/L upon discussion with the coordinating investigator
               3. Evidence of autoimmune hemolytic anemia manifested as a corrected reticulocyte
                  count of > 2% with either a positive direct anti-globulin test (DAT) or over 50%
                  of indirect bilirubin
               4. Creatinine clearance <50 ml/minute as calculated by the CockcroftGault formula or
                  serum creatinine of ≥ 1.5 x ULN.
               5. Absolute WBC (white blood cell count) ≥ 20 x 109/L f ) Participants with isolated
                  individual lab abnormalities considered to be disease related will be considered
                  individually in consultation with the Coordinating Principal Investigator.
         16. Known or suspected hypersensitivity to study drugs or their constituents.
         17. Pregnant or breast-feeding.
         18. Any condition not already outlined above which, in the opinion of the clinical
             investigator, would place the participant at risk if they participated or would
             jeopardise adherence or follow up or confound the ability to interpret study data.