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Vaccination Against COVID-19 in Chronic Kidney Disease

Vaccination Against COVID-19 in Chronic Kidney Disease

Recruiting
18 years and older
All
Phase N/A

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Overview

This is a prospective, multi-center, observational study that will enroll patients receiving dialysis (hemodialysis or peritoneal dialysis) or patients with kidney transplantation who will be vaccinated against COVID-19.

Description

Patients on dialysis and kidney transplant patients infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) have an increased risk to develop a more severe course of disease or die from COVID-19 (coronavirus disease 2019). SARS-CoV-2 vaccination can increase protection against COVID-19. Kidney transplant patients and patients requiring dialysis suffer from an acquired immune deficiency. Due to the dysfunctional immune response, the general vaccine response in dialysis patients and kidney transplant patients is in many cases insufficient.

Until now, the vaccination response in dialysis patients and kidney-transplanted patients is unpredictable. Verification of vaccine response can provide important information on how to treat and protect these patients from a COVID-19. Therefore, there is a medical need to monitor vaccine protection after SARS-CoV-2 vaccination in clinical practice. In this observational study, data of the SARS-CoV-2 vaccination response collected in clinical routine will be analyzed from these patients. Based on this observational study, the investigators aim to get first evidence whether and to what extent vaccination against COVID-19 causes a vaccine response in immunocompromised patients with kidney disease.

Eligibility

Inclusion Criteria:

  • receiving dialysis (hemodialysis or peritoneal dialysis)
  • capable of giving consent
  • age 18 or older

Exclusion Criteria:

  • non-capable of giving consent

Study details
    Chronic Kidney Disease Stage 5 on Dialysis
    Chronic Kidney Disease Stage 5 With Transplant
    Vaccine Response Impaired

NCT04743947

Heinrich-Heine University, Duesseldorf

27 January 2024

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