Acetaminophen and AKI After Aortic Surgery

Overview

Acute kidney injury is commonly accompanied major complication after aortic surgery.

Cardipulmonary bypass lyses erythrocyte and induces lipid peroxidation. This increases plasma free hemoglobin, F2-isoprostane, and isofuran concentration. Cell free hemoglobin have been reported to be associated with poor prognosis such as acute kidney injury, myocardial infarction, and death.

Acetaminophen is reported to attenuate hemeprotein mediated lipid peroxidation. Thus, investigators hypothesized that acetaminophen might have protective effect on the incidence of acute kidney injury in patients undergoing aortic surgery with moderate hypothermic circulatory arrest.

Eligibility

Inclusion Criteria:

1. Patients undergoing aortic surgery with moderate hypothermic circulatory arrest.

Exclusion Criteria:

1. patients with chronic kidney disease or with dialysis, eGFR < 15ml/min/1.73m2
2. allergy to acetaminophen or propacetamol HCl
3. history of liver cirrhosis or total bilirubin > 2.0mg/dL
4. patients taking acetaminophen or diclofenac 4) patients who cannot understand informed consent