Overview

To investigate the feasibility and peri-operative complications of preoperative hypo-fractionated radiotherapy followed by surgery for retroperitoneal sarcoma

Eligibility

Inclusion Criteria:

• Primary soft tissue sarcoma of retroperitoneal or infra-peritoneal spaces of pelvis
• Sarcoma not originated from bone structure, abdominal or gynecological viscera
• All disease can be included safely within one radiotherapy field
• Absence of extension through the sciatic notch or across the diaphragm
• Histologically proven, excluding the following subtypes: Gastro-intestinal stromal tumors (GIST), rhabdomyosarcoma, PNET or other small round blue cells sarcoma, osteosarcoma or chondrosarcoma, aggressive fibromatosis, sarcomatoid or metastatic carcinoma
• ECOG performance status 0 to 2
• American Society of Anesthesiologist (ASA) score ≤2
• Normal renal function: Calculated Creatinine Clearance ≥50ml/min（by Cockcroft-Gault formula）and functional contralateral kidney by differential renal isotope scan
• Normal bone marrow and hepatic function.
• Contraception was needed for female patients of child-bearing age, or male patients whose partner had child-bearing age
• expected life expectancy longer than 5 years
• Written consent form was given prior to treatment
• Can safely be treated by radiotherapy and surgery

Exclusion Criteria:

• metastatic disease
• Tumor was previously treated by radiotherapy
• Involvement of liver, pancreatic head or duodenum