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A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)

A Study Using Human Papillomavirus (HPV) DNA Testing to Detect HPV-Related Oropharyngeal Cancer (OPC)

Non Recruiting
45 years and older
All
Phase N/A

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Overview

The researchers think that a blood test (NavDx®) may be able to identify cancer early by looking for circulating DNA from Human Papillomavirus/HPV. Circulating DNA are small pieces of genes that are released into the bloodstream. The purpose of this study is to find out whether using this blood test to test for HPV DNA will help detect HPV-related Oropharyngeal Cancer/OPC.

Eligibility

Inclusion Criteria:

  • Ages 45 and older
  • Self-reported history of four or more lifetime sexual partners
  • Self-reported history of one or more lifetime oral sexual partner
  • No previous history of diagnosed HPV-related head and neck cancer

Exclusion Criteria:

  • History of diagnosed HPV-related OPC
  • Less than three sexual partners in lifetime
  • No history of oral sex performed
  • Younger than age 45

Study details
    Oropharyngeal Cancer
    HPV-Related Carcinoma
    HPV Positive Oropharyngeal Squamous Cell Carcinoma

NCT05814549

Memorial Sloan Kettering Cancer Center

21 October 2025

FAQs

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