Overview

This is a single-centre, phase 1a (dose escalation) and 1b (dose expansion) study to evaluate the safety and tolerability of oral Selinexor in combination with nivolumab and ipilimumab in patients with advanced solid malignancies.

Eligibility

Inclusion Criteria:

1. Age ≥ 21
2. Willing and able to provide written informed consent in accordance with local institutional guidelines.
3. Dose Escalation Phase: Patients with histologically or cytologically confirmed advanced or metastatic solid tumors who have radiological evidence of progressive disease on study entry that is deemed unlikely to benefit from further standard therapy.
4. Dose Expansion phase: Patients with previously treated, metastatic or advanced recurrence malignancy confirmed histologically or cytologically. Patients must have evidence of progressive disease on study entry that is deemed unlikely to benefit from further standard therapy.
5. There is no upper limit on the number of prior treatments. Hormone ablation therapy is considered an anticancer regimen. Radiation and surgery are not considered anticancer regimens.
6. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0-1.
7. Adequate hepatic function within 14 days prior to C1D1:
   1. Total bilirubin < 1.5 × upper limit of normal (ULN) (except patients with Gilbert's syndrome who must have a total bilirubin of < 3 × ULN), and
   2. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) normal to <3 × ULN.
8. Adequate renal function within 14 days prior to C1D1 as determined by serum creatinine

   of ≤1.5 mg/dL OR estimated creatinine clearance of ≥ 30 mL/min, calculated using the Cockcroft and Gault formula (140 - Age) • Mass (kg)/ (72 • creatinine mg/dL); multiply by 0.85 if female.

9. Adequate hematopoietic function within 14 days prior to C1D1. Transfusions and growth factors are allowed prior to and throughout the study.
   1. Total white blood cell (WBC) count ≥1500/mm3, absolute neutrophil count ≥1000/mm3
   2. Hemoglobin ≥9 g/dL
   3. Platelet count ≥125,000/mm3 in dose escalation phase, and platelet count ≥100,000/mm3 in dose expansion phase.
10. Female patients of childbearing potential must have a negative serum pregnancy test at

    Screening. Female patients of childbearing potential and fertile male patients who are sexually active with a female of childbearing potential must use highly effective methods of contraception throughout the study and for 5 months following the last dose of study treatment.

    1. Female patients of childbearing potential and fertile male patients must agree to use highly effective contraception listed below (ie, results in a low failure rate when used consistently and correctly) during the dosing period and for a period of at least 5 months after the end of treatment.
    2. Highly effective methods include: i. combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation:
       1. oral 2. intravaginal 3. transdermal ii. progestogen-only hormonal contraception associated with inhibition of ovulation:
11. oral
12. injectable
13. implantable iii. intrauterine device iv. intrauterine hormone-releasing system v. bilateral tubal occlusion vi. vasectomized partner vii. sexual abstinence

Exclusion Criteria:

        Exclusion criteria 1. Patients with significant medical illness that in the investigator's
        opinion cannot be adequately controlled with appropriate therapy or would compromise the
        patient's ability to tolerate this therapy; 2. Radiation (except planned or ongoing
        palliative radiation to bone outside of the region of measurable disease) ≤ 3 weeks prior
        to cycle 1 day 1 3. Chemotherapy, or immunotherapy or any other systemic anticancer therapy
        ≤ 3 weeks prior to cycle 1 day 1.
        4. Uncontrolled active infection requiring systemic antibiotics (Hepatitis B and C
        infection are NOT exclusion criteria).
        1. Subjects with active hepatitis B virus (Hep B) are allowed if antiviral therapy for
        hepatitis B has been given for >8 weeks and viral load is <100 IU/ml prior to first dose of
        trial treatment. Subjects with untreated hepatitis C virus (HCV) are allowed. Subjects with
        Human Immunodeficiency Virus (HIV) who have CD4+ T-cell counts ≥ 350 cells/µL and no
        history of AIDS-defining opportunistic infections in the last year are allowed.
        5. Major surgery within 2 weeks of first dose of study drug. 6. Patients who are pregnant
        or breast-feeding; 7. Patients with significantly diseased or obstructed gastrointestinal
        tract, malabsorption, uncontrolled vomiting or diarrhea or inability to swallow oral
        medications.
        8. Patients with serious psychiatric or medical conditions that could interfere with
        treatment.
        9. History of organ allograft 10. Patients who had previous grade 4 immune related adverse
        events from prior immunotherapy (including anti PD-1/PD-L1 or anti CTLA-4 antibodies).
        11. Patients who previously received Selinexor and had grade 4 non laboratory adverse
        events that were considered treatment related or possibly treatment related.
        12. Concurrent therapy with approved or investigational anticancer therapeutics; 13.
        Patients receiving chronic treatment with systemic steroid therapy (>10 mg/day prednisone
        or equivalent) within 7 days of the first dose of study treatment, other than
        replacement-dose steroids in the setting of adrenal insufficiency. Topical,inhaled, nasal
        and ophthalmic steroids are not prohibited.
        14. Active or prior documented autoimmune or inflammatory disorders (including inflammatory
        bowel disease [eg, colitis or Crohn's disease], diverticulitis [with the exception of
        diverticulosis], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome
        [granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis,
        uveitis, etc]). The following are exceptions to this criterion:
          1. Subjects with vitiligo or alopecia
          2. Subjects with hypothyroidism (eg, following Hashimoto syndrome) stable on hormone
             replacement
          3. Any chronic skin condition that does not require systemic therapy
          4. Subjects without active disease in the last 5 years may be included but only after
             consultation with the medical monitor
          5. Subjects with celiac disease controlled by diet alone
          6. For other autoimmune or inflammatory conditions not specifically mentioned - to
             discuss on case by case basis with investigator and medical monitor 15. BSA <1.35 m2
             (BSA calculated by Dubois or Mosteller methods)