Description

This study uses functional magnetic resonance imaging (fMRI) is a ultra-fast imaging technology to reflect the changes in brain function when the brain is stimulated or pathologically affected. There are 4 working imaging techniques for fMRI,including blood-oxygen-level dependent fMRI,perfusion weighted imaging(PWI),perfusion weighted imaging(PWI) and MRI spectroscopy.fMRI combine with cloud computing to analyze brain structure, brain function, brain connection,brain development trajectory,multi-modal brain imaging artificial Intelligent calculation, and draw dynamic connection map of the brain development in children aged 0-6 years.In addition,using the Chinese Urban Children's Emotion and Social Assessment Scale (CITSEA) to evaluate children's social and emotional behavior and Gesell Developmental Scale(GDS) to assess neurological integrity and functional maturity of children, and explore their relationship with brain imaging.Blood samples of enrolled subjects will be taken for the Whole Exon Sequencing to find genes implicated in brain intellectual development, and explore its relationship with brain imaging.This study explores the relationship between brain development and infants' social emotion and communication ability, as well as the role of genetic factors in it.To provide a theoretical basis for precise intervention of infants' social emotion and communication problems and the overall improvement of brain development.