Overview

The goal of this study is to determine the number of servings of broccoli sprouts sufficient to (1) increase sulforaphane levels in the stool and blood and (2) reduce inflammatory markers in patients with mild ulcerative colitis. This is a pilot feasibility study to prepare for a larger randomized controlled trial.

Eligibility

Inclusion Criteria:

• Documented endoscopic diagnosis of ulcerative colitis
• Mild ulcerative colitis based on endoscopic findings and/or fecal calprotectin levels=50-500 mg/g stool.
• Currently being treated with a stable dose of 5-ASAs, steroids, Imuran, Remicade, or Humira, defined as such:
  • If on 5-ASA, no dose changes within 2 weeks before the Day 0 visit
  • If on steroids, prednisone dose not more than 20 mg daily and entocort not more than 9 mg daily, with no dose changes within 2 weeks before the Day 0 visit
  • If on Imuran, Remicade, or Humira, no dose changes within 8 weeks before the Day 0 visit
  • No dose changes to any IBD medication anticipated for the duration of the study
• Body Mass Index (BMI) values 18.5-40 kg/m2
• Not on total parenteral nutrition (TPN) or receiving tube feeds.
• Ability to understand the study procedures, benefits and risks, and sign a written informed consent document.
• Able to fill out questionnaires regarding dietary intakes, bowel symptoms, and study experience

Exclusion Criteria:

• Taking Non-steroidal anti-inflammatory drugs (NSAIDs) or biologic/immunomodulatory therapies
• Following a medically-prescribed diet, on Total parenteral nutrition (TPN), or tube feeds
• Newly diagnosed (within past month), or uncontrolled diabetes or cardiovascular disease
• Antibiotics in the previous 2 weeks
• Consumption of more than 5 ½ cups of servings/day of fruits and vegetables as assessed by the National Cancer Institute (NCI) Diet History Questionaire III online Food Questionnaire.