Overview
This study involves the one-time collection of whole blood or saliva samples for the extraction and storage of DNA for use in ongoing and future ChiLDReN studies.
Description
The purpose of this study is to establish a mechanism to collect a genetic biosample from the participants and their biological parents previously enrolled into clinical research under ChiLDReN-supported protocols (PROBE, BASIC, LOGIC, and MITOHEP). The samples will be linked to the data previously collected on the participant. Samples will be stored in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) specimen repository and will be used in ongoing and future Network and Ancillary Studies of ChiLDReN to further address the pathophysiology and outcomes of these liver diseases.
Eligibility
Inclusion Criteria:
- For Child Participants
- Previous enrollment in PROBE, BASIC, LOGIC, or MITOHEP
- Exited from one of the aforementioned studies.
- Consent for DNA sample collection obtained during enrollment during enrollment to one of the aforementioned studies but sample not previously collected.
- Still followed at the clinical site.
- For Biological Parent Participants
- Biological parents of previously consented child participant without collection of a parental DNA biospecimen.
- Child still followed at the clinical site.
Exclusion Criteria:
- For Child Participants
- Participant is deceased
- Participant exited from prior study due to violating eligibility criteria
- Participant cannot be contacted
- For Biological Parent Participants
- Non-biological parent
- Child DNA was not previously collected and will not be collected in this study