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Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Recruiting
40 years and older
All
Phase N/A
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Overview

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Eligibility

Inclusion criteria:

  • Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
  • Planned clinical electrode trajectory that contacts caudate
  • Age greater than or equal to 40
  • Diagnosis of Parkinson's disease
  • Able to participate in intraoperative testing
  • English speaking

Exclusion criteria:

  • Age less than 40
  • Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
  • Movement disorder other than Parkinson's disease

Study details
    Parkinson Disease

NCT04715984

Vanderbilt University Medical Center

27 January 2024

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